Fear among baseline humans becomes wide-spread panic as world leaders are unable to deal with all the new powered people in the world. The hysteria ultimately leads to the ratification of the Superhuman Registration Act.

The act, implemented through the world security organization known as S.H.I.E.L.D., would force the registration of all powered people into a global database that allows nations to track the proliferation of powers within their borders.

It would be the mutant "Destiny", who foretells of a global war with superhumans as weapons of mass destruction. Most in the Superhuman community are unified in opposition to registration until the incident in Stamford Connecticut where a team of inexperienced superheroes are responsible for the deaths of over 400 men, women, and children.

A split is created in the Superhuman community with Iron Man believing that Stamford highlights the need for more controls and Captain America believing that Destiny's visions could come to pass because of abuse of power the Act allows.

This leads to the Premise of the game and where you, the player, enters the universe.